Outcomes of Wound Healing after Plasma-Rich Platelet Therapy
Keywords:
Chronic wound, non healing wound, plasma rich platelet therapy, ourcomes after therapy, wound managementAbstract
OBJECTIVE: To identify outcomes of wound healing after using Plasma Rich platelet therapy.
METHODOLOGY: A prospective cross-sectional study was conducted at ISRA University Hospital, Hyderabad, from July to December 2022, with a sample size of 50 and a non-probability sampling technique. Both genders aged 45 to 75 years, Diabetes mellitus type II, Chronic or Non-healing wounds/ulcers for 3 to 6 months, and Wound size 2cm to 6cm were included. Participants who were not willing to study, Patients on steroid and Anticoagulant therapy and Immunosuppressive drugs, Pregnant females, those with Cardiovascular Disorders, and Associated Lymphoedema were excluded. Data was analyzed by SPSS version 21.
RESULTS: Fifty patients were enrolled after matching the inclusion and exclusion criteria. The age range was 40 years to 70 years. Thirty-one were males, and 19 were females. Co-morbid conditions included were diabetes mellitus type II and hypertension. The most common cause of lower limb ulcers was diabetic foot, and the most common site was the dorsum of the foot. 52% of patients had <2cm size ulcers, and they responded well to plasma-rich platelet therapy in a single session. PRP is a cost-effective, advanced therapy and safe procedure to manage wound healing. It improves quality of life, reduces hospitalization, and decreases hospital visits, which would lessen the patient burden. It works on cellular regeneration, so it helps in faster recovery and avoidance of old traditional methods and excessive or misuse of antibiotics.
CONCLUSION: Plasma Rich Platelet therapy is a safe method for treating chronic and non-healing ulcers.
References
Chicharro-Alcántara D, Rubio-Zaragoza M, Damiá-Giménez E, Carrillo-Poveda JM, Cuervo-Serrato B, Peláez-Gorrea P et al. Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management. J Funct Biomater. 2018; 9(1): 10. doi: 10.3390/jfb9010010.
Sebastian KMS, Lobato I, Hernandez I, Burgos-Alonso N, Gomez-Fernandez MC, Lopez JL et al. Efficacy and safety of autologous platelet-rich Plasma for the treatment of vascular ulcers in primary care: phase III study. BMC Fam Pract. 2014; 15: 211. doi: 10.1186/s12875-014-0211-8.
Martinez-Zapata MJ, Martí-Carvajal AJ, Solà I, Expósito JA, Bolíbar I, Rodríguez L et al. Autologous platelet-rich Plasma for treating chronic wounds. Cochrane Database Syst Rev. 2016; 2016(5): CD006899. doi: 10.1002/14651858.CD006899.pub3.
Teng M, Huang Y, Zhang H. Application of stems cells in wound healing-An update. Wound Repair Regen. 2014; 22(2): 151-60. doi: 10.1111/wrr.12152.
Cialdai F, Colciago A, Pantalone D, Rizzo AM, Zava S, Morbidelli L et al. Effect of Unloading Condition on the Healing Process and Effectiveness of Platelet Rich Plasma as a Countermeasure: Study on In Vivo and In Vitro Wound Healing Models. Int J Mol Sci. 2020; 21(2): 407. doi: 10.3390/ijms21020407.
Frykberg RG, Banks J. Challenges in the Treatment of Chronic Wounds. Adv Wound Care(New Rochelle). 2015; 4(9): 560-82. doi: 10.1089/wound.2015.0635.
Akhtar S, Latif M, Ahmed OS, Sarwar A, Alina A, Khan MI. Prevalence of foot ulcers in diabetic patients in Punjab, Pakistan. Front Public Health. 2022; 10: 967733. doi: 10.3389/fpubh.2022.967733.
Agale SV. Chronic Leg Ulcers: Epidemiology, Aetiopathogenesis, and Management. Ulcers. 2013; 2013: 1-9. doi: 10.1155/2013/413604.
Suthar M, Gupta S, Bukhari S, Ponemone V. Treatment of chronic non-healing ulcers using autologous platelet-rich plasma: a case series. J Biomed Sci. 2017; 24(1): 16. doi: 10.1186/s12929-017-0324-1.
Giuggioli D, Colaci M, Manfredi A, Mariano M, Ferri C. Platelet gel in the treatment of severe scleroderma skin ulcers. Rheumatol Int. 2012; 32(9): 2929-32. doi: 10.1007/s00296-011-2038-0. Epub 2011 Jul 27.
Marx RE. Platelet-rich Plasma: evidence to support its use. J Oral Maxillofac Surg. 2004; 62(4): 489–96. doi: 10.1016/j.joms.2003.12.003.
Elsaid A, El-Said M, Emile S, Youssef M, Khafagy W, Elshobaky A. Randomized Controlled Trial on Autologous Platelet-Rich Plasma Versus Saline Dressing in Treatment of Non-healing Diabetic Foot Ulcers. World J Surg. 2020; 44(4): 1294-1301. doi: 10.1007/s00268-019-05316-0.
Aymen Salem A, Tawfik A. Role of Platelet Rich Plasma in Treatment of Diabetic Foot Ulcers. Surg Sci. 2016; 7(6): 272-277. Doi: 10.4236/ss.2016.76038.
Smith OJ, Leigh R, Kanapathy M, Macneal P, Jell G, Hachach-Haram N et al. Fat grafting and platelet-rich plasma for the treatment of diabetic foot ulcers: A feasibility-randomized controlled trial. Int Wound J. 2020; 17(6): 1578-94. doi: 10.1111/iwj.13433.
Ullah A, Jawaid SI, Qureshi PNAA, Siddiqui T, Nasim K, Kumar K et al. Effectiveness of Injected Platelet-Rich Plasma in the Treatment of Diabetic Foot Ulcer Disease. Cureus. 2022; 14(8): e28292. doi: 10.7759/cureus.28292.
Fibrini D, Lister NE. Pilot study on the effect of autologous activated platelet-rich plasma on diabetic foot ulcer wound healing and serum HbA1c levels. J Pharm Pharmacogn Res. 2023; 11(2): 263-9. doi: 10.56499/jppres22.1555_11.2.263.
Shehata MS, Rezk AA. Assessment General Surgery of Platelet Rich Plasma (PRP) Therapy in Prevention of Chronic Wound Complications. Al-Azhar Int Med J. 2021; 2(12): 35-9. doi: 10.21608/aimj.2021.99187.1591.
El-Einen HA, El-Haseeb AA, El-Aziz IA, Massoud A. Role of Platelet Rich Plasma in Management of Diabetic Wound in Ischemic Lower Limb (after revascularization). Egypt J Med Res. 2020; 1(2): 37-48. doi: 10.21608/ejmr.2020.90105.
Gan F, Wang R, Lyu P, Li Y, Fu R, Du Y et al. Plasma-Derived Exosomes Boost the Healing of Irradiated Wound by Regulating Cell Proliferation and Ferroptosis. J Biomed Nanotechnol. 2021; 17(1): 100-114. doi. 10.1166/jbn.2021.3008.
Hu ZB, Chen HC, Wei B, Zhang Z-M, Wu S-K, Sun J-C et al. Platelet rich plasma enhanced neuro-regeneration of human dental pulp stem cells in vitro and in rat spinal cord. Ann Transl Med. 2022; 10(10): 584. doi: 10.21037/atm-22-1745.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Journal of Liaquat University of Medical & Health Sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Submission of a manuscript to the journal implies that all authors have read and agreed to the content of the undertaking form or the Terms and Conditions.
When an article is accepted for publication, the author(s) retain the copyright and are required to grant the publisher the right of first publication and other non-exclusive publishing rights to JLUMHS.
Articles published in the Journal of Liaquat University of Medical & health sciences are open access articles under a Creative Commons Attribution-Noncommercial - Share Alike 4.0 License. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal. This is in accordance with the BOAI definition of open access. In addition to that users are allowed to remix, tweak and build upon the work non-commercially as long as appropriate credit is given and the new creations are licensed under the identical terms. Or, in certain cases it can be stated that all articles and content there in are published under creative commons license unless stated otherwise.