Effect of Hyperbaric Oxygen Therapy Dose on Post-Replantation of the Distal Phalanx of Digiti II Manus Sinistra

Authors

  • Titut Harnanik
  • Made Kanya Emeralda Pradnyapramesti
  • Nyoman Sayang Jayarta

Keywords:

HBOT dose, Post-replantation, Growth Factors, Angiogenesis, Collagen formation, Epithelialization

Abstract

Finger replantation in adults requires a more extended healing period and is at risk of failure. Giving hyperbaric oxygen therapy (HBOT) at the correct dose can speed healing, reducing the risk of failure. A case involved a 32-year-old woman after replantation of the distal phalanx of digiti II manus sinistra of the patient who experienced cyanosis and necrosis. This report analyzes the relationship between HBOT dose and accelerated stimulation of growth factors that can improve the wound healing process.

Replantation refers to the reconnection of an amputated body part to its anatomical structure to restore the function of the injured part. The outcome depends on the dose of HBOT, the patient's intrinsic factors, and the nature of the injury. Giving HBOT once a day, in this case, was not effective because the patient's fingertips became more cyanotic, and necrosis increased. Providing the correct dose of HBOT twice a day accelerates overcoming hypoxia. It helps successfully heal wounds through angiogenesis, collagen formation, and epithelialization, so new tissue growth is expected to accelerate.

References

Alshehri FM, Ahmed SA, Ullah S, Ghazal H, Nawaz S, Alzahrani AS. The Patterns of Acquired Upper and Lower Extremity Amputation at a Tertiary Centre in Saudi Arabia. Cureus. 2022; doi:10.7759/cureus.24026.

Altam A, Obadiel Y, Alazaiza RS, Alshujaa MA, Alhajami F, Ahmed F et al. Microsurgical Digits Replantation in Resource-Limited Setting: A Retrospective Study. Open Access Emerg Med. 2024; 16: 1–13. doi: 10.2147/OAEM.S443219.

Sen S. Therapeutic effects of hyperbaric oxygen: Integrated review. Med Gas Res. 2021; 11: 30-33 Preprint at https://doi.org/10.4103/2045-9912.310057.

Jain KK. Physical, Physiological, and Biochemical Aspects of Hyperbaric Oxygenation. in Textbook of Hyperbaric Medicine. 11–22 (Springer Int Publishing, 2017). doi: 10.1007/978-3-319-47140-2_2.

Ortega MA, Fraile-Martinez O, García-Montero C, Callejón-Peláez E, Sáez MA, Álvarez-Mon MA et al. A general overview on the hyperbaric oxygen therapy: Applications, mechanisms and translational opportunities. Medicina (Lithuania). 2021; 57. Preprint at https://doi.org/10.3390/medicina57090864.

Mao, Y, Liu, X, Song Y, Zhai C, Zhang, L. VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-? play important roles in promoting immature and inflammatory intraplaque angiogenesis. PLoS One. 2018; 13. doi: 10.1371/journal.pone.0201395.

Wang K, Wen D, Xu X, Zhao R, Jiang F, Yuan S et al. Extracellular matrix stiffness - The central cue for skin fibrosis. Front Mol Biosci. 2023; 10. Preprint at https://doi.org/10.3389/fmolb.2023.1132353.

Chen Y, Jiang L, Lyu K, Lu J, Long L, Wang X et al. A Promising Candidate in Tendon Healing Events—PDGF-BB. Biomolecules. 2022; 12. Preprint at https://doi.org/10.3390/biom12101518.

Zhang Z, Yao L, Yang J, Wang Z, Du G. PI3K/Akt and HIF-1 signaling pathway in hypoxia-ischemia (Review). Mol Med Rpts. 2018; 18: 3547–3554. Preprint at https://doi.org/10.3892/mmr.2018.9375.

Wang Y, Xu J, Zhang X, Wang C, Huang Y, Dai K et al. TNF-?-induced LRG1 promotes angiogenesis and mesenchymal stem cell migration in the subchondral bone during osteoarthritis. Cell Death Dis. 2017; 8: e2715–e2715. doi: 10.1038/cddis.2017.129.

de Wolde SD. The Effect of Hyperbaric Oxygen Therapy on Markers of Oxidative Stress and the Immune Response in Healthy Volunteers. Front Physiol. 2022; 13. doi: 10.3389/fphys.2022.826163.

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Published

27-03-2025

How to Cite

1.
Harnanik T, Pradnyapramesti MKE, Jayarta NS. Effect of Hyperbaric Oxygen Therapy Dose on Post-Replantation of the Distal Phalanx of Digiti II Manus Sinistra. J Liaq Uni Med Health Sci [Internet]. 2025 Mar. 27 [cited 2025 Apr. 24];24(01):69-73. Available from: http://121.52.154.205/index.php/jlumhs/article/view/1386

Issue

Vol. 24 No. 01 (2025): Journal of Liaquat University of Medical & Health Sciences

Section

Case Reports

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