Network Pharmacological Study of Papaver Somniferum to Explore the Potential Compounds to Treat Epilepsy
Keywords:
Papaver somniferum, epilepsy, network pharmacology, Molecular docking, Medicinal plants, PPI network.Abstract
Objective: This study aims to discover potential compounds of Papaver somniferum for epilepsy treatment using network pharmacology and molecular docking tools.
Methodology: Papaver somniferum compounds were obtained from KNApSAcK and the IMPPAT database. Potential epilepsy targets were obtained from DisGeNET and GeneCards. After identifying common targets using a Venn diagram, DAVID analysis was performed. STRING database was used for protein-protein interactions, and Cytoscape was used for visualization and construction of target-compound-pathway network. Molecular docking was performed to identify potential active ingredients against epilepsy.
Results: Fifteen active ingredients and 343 therapeutic targets were obtained from Papaver somniferum, and 7784 and 1215 epilepsy disease genes resulted in 79 common targets. Hub genes were identified using topological analysis. Molecular docking studies demonstrated that 15 active compounds possess the potential to bind the epilepsy targets.
Conclusion: Network pharmacology and molecular docking identified potential multitargeting compounds such as salutaridine, scoulerine, gamma-isomorphine, morphine, Codeine, Codeinone, (S)-Scoulerine and (-)-Codeinone for Epilepsy treatment.
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