Presentation of Tuberculous Meningitis

Authors

  • Salma Haji

Abstract

Objective: To find out the frequency of presentation of Tuberculous meningitis in different stages and to assess the role of Cerebrospinal fluid analysis and Magnetic Resonance imaging in diagnosis.

Methodology: This descriptive observational study was conducted at neurology ward at JPMC Karachi from July 2018 - December 2019. Diagnosed patients of tuberculous meningitis above 12 years of age included in the study and were classified into three stages. Stage 1 included non-specific symptoms like headache, vomiting, fever and anorexia without impaired level of consciousness. Stage 2 patients were altered level of consciousness or focal neurological deficit without coma. Stage 3 patients included coma, Cerebrospinal fluid analysis and Magnetic Resonance imaging findings were recorded. Mortality was recorded in Performa. Other variables like age, sex, residence etc. were recorded. Data was analyzed by SPSS version 24.

Results: Patients were 110, presented in stage 1 were 30%( 33/110). In stage 2, 60 %( 66/110) and in stage 3, 10%(11/110). Mortality was 10% and patients who expired were presented in stage 3. Tuberculous Meningitis patients presented with neck stiffness 98.18(108/110), headache 70%
(77/110), anorexia 60%(66/110), sign of meningeal irritation 50%(55/110) and 40%(44/110) cranial nerve palsies 40%. The Cerebrospinal fluid findings were raised protein (63.63) lymphocytosis 99.91%(109/110) low glucose 98.18%(108/119) Magnetic Resonant Imaging findings were meningeal enhancement 49.09%(54/110).

Conclusion: Tuberculous meningitis patients presented predominantly in stage 2(60%) then stage 1 (30%) and in stage 3 (10%). Cerebrospinal fluid analysis and Magnetic Resonance Imaging are good diagnostic investigation for Tuberculous Meningitis. Sign and symptoms were usually non-specific.

 Key Words: Tuberculous Meningitis, Cerebrospinal fluid, presentation of Tuberculous meningitis, stages of Tuberculous Meningitis 

Downloads

Published

07-10-2020

How to Cite

1.
Haji S. Presentation of Tuberculous Meningitis. J Liaq Uni Med Health Sci [Internet]. 2020 Oct. 7 [cited 2024 Nov. 15];19(03):167-70. Available from: http://121.52.154.205/index.php/jlumhs/article/view/398

Issue

Vol. 19 No. 03 (2020): Journal of Liaquat University of Medical & Health Sciences

Section

Original Articles

License

Submission of a manuscript to the journal implies that all authors have read and agreed to the content of the undertaking form or the Terms and Conditions.

When an article is accepted for publication, the author(s) retain the copyright and are required to grant the publisher the right of first publication and other non-exclusive publishing rights to JLUMHS.

Articles published in the Journal of Liaquat University of Medical & health sciences are open access articles under a Creative Commons Attribution-Noncommercial - Share Alike 4.0 License. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal. This is in accordance with the BOAI definition of open access. In addition to that users are allowed to remix, tweak and build upon the work non-commercially as long as appropriate credit is given and the new creations are licensed under the identical terms. Or, in certain cases it can be stated that all articles and content there in are published under creative commons license unless stated otherwise.