Hyaluronic Acid act as a Non - Invasive Marker for Diagnosis of Liver Fibrosis in the Patients of Chronic Hepatitis C

Authors

  • Muhammad Akram
  • Ali Raza Memon
  • Pushpa .
  • Farman Ullah Farman
  • Muhammad Imtiaz Shafiq

Keywords:

Hyaluronic acid, Liver fibrosis, Hepatitis C

Abstract

OBJECTIVE: To evaluate the biochemical significance of Hyaluronic acid in liver fibrosis among
chronic hepatitis C patients to eliminate repetitive liver biopsies.
METHODOLOGY: Cross Sectional Comparative Analytical Study at FPGMI, Shaikh Zayed
Hospital, Lahore from January 2017 to December 2017. This cross-sectional study, included patients of
chronic hepatitis C (n = 250) along with controls (n =100). Serum hyaluronic acid assay (patients &
controls) was performed using enzyme linked binding protein assay, using a capture molecule known
as hyaluronic acid binding protein (HABP) along with quantitative Echelon (Echelon biosciences Inc.
USA) used as reference standard.
RESULTS: Total 350 participant both male and females participated for this study from these 350
samples, 100 normal samples were recruited as control group and 250 diagnosed cases of chronic
hepatitis C patients were recruited as case study group. Serum Hyaluronic acid was significantly
(P<0.001) elevated in patients (195.77 ±6.67) compared to controls (110.2 ±0.79) irrespective of gender
involvement.
CONCLUSION: The current findings showed significant involvement of HA in early prognosis of liver
fibrosis and cirrhosis among chronic HCV patients that would probably useful to reduce repetitive liver
biopsy.

Downloads

Published

11-04-2019

How to Cite

1.
Akram M, Memon AR, . P, Farman FU, Shafiq MI. Hyaluronic Acid act as a Non - Invasive Marker for Diagnosis of Liver Fibrosis in the Patients of Chronic Hepatitis C. J Liaq Uni Med Health Sci [Internet]. 2019 Apr. 11 [cited 2024 Nov. 15];17(03):161-4. Available from: http://121.52.154.205/index.php/jlumhs/article/view/73

Issue

Vol. 17 No. 03 (2018): Journal Of Liaquat University of Medical & Health Sciences

Section

Original Articles

License

Submission of a manuscript to the journal implies that all authors have read and agreed to the content of the undertaking form or the Terms and Conditions.

When an article is accepted for publication, the author(s) retain the copyright and are required to grant the publisher the right of first publication and other non-exclusive publishing rights to JLUMHS.

Articles published in the Journal of Liaquat University of Medical & health sciences are open access articles under a Creative Commons Attribution-Noncommercial - Share Alike 4.0 License. This license permits use, distribution and reproduction in any medium; provided the original work is properly cited and initial publication in this journal. This is in accordance with the BOAI definition of open access. In addition to that users are allowed to remix, tweak and build upon the work non-commercially as long as appropriate credit is given and the new creations are licensed under the identical terms. Or, in certain cases it can be stated that all articles and content there in are published under creative commons license unless stated otherwise.